Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC046
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-12 11:57
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 4x1/4 caps HBS q uvece u 22h New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 10, 'TN': 9, 'TP': 32, 'FP': 21}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 7, 'TN': 5, 'TP': 35, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 9.592
timePerCircleCoV 0.284622
timePerCircleSlope -0.0491319
meanError 1.51769
tremorFreq 5.85938
tremorRelPower 25.1721
tremorGyroAmpMean 0.0172435
tremorGyroAmpSlope 0.00116612
tremorGyroAmpCoV 0.349081
tremorCoordAmpMean 0.0339033
tremorCoordAmpSlope 0.00368205
tremorCoordAmpCoV 0.516377
tremorAccAmpMean 0.0454478
tremorAccAmpSlope -0.000322294
tremorAccAmpCoV 0.0898861
tremorPcRelVar 0.563616
tremorPcX -0.825357
tremorPcY 0.564611

Circle Segment 1

Duration 17.2 s, Accuracy Estimate 1.383 (lower is better)

Circle Segment 2

Duration 9.52 s, Accuracy Estimate 1.737 (lower is better)

Circle Segment 3

Duration 8.32 s, Accuracy Estimate 1.537 (lower is better)

Circle Segment 4

Duration 8.56 s, Accuracy Estimate 1.265 (lower is better)

Circle Segment 5

Duration 9.2 s, Accuracy Estimate 1.786 (lower is better)

Circle Segment 6

Duration 8.0 s, Accuracy Estimate 1.193 (lower is better)

Circle Segment 7

Duration 8.48 s, Accuracy Estimate 1.54 (lower is better)

Circle Segment 8

Duration 9.24 s, Accuracy Estimate 1.583 (lower is better)

Circle Segment 9

Duration 8.04 s, Accuracy Estimate 1.382 (lower is better)

Circle Segment 10

Duration 9.36 s, Accuracy Estimate 1.772 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 17.688
timePerSpiralCoV 0.164118
timePerSpiralSlope -0.014199
meanError 2.16192
tremorFreq 6.93359
tremorRelPower 23.0954
tremorGyroAmpMean 0.0155026
tremorGyroAmpSlope 0.00225761
tremorGyroAmpCoV 0.388242
tremorCoordAmpMean 0.0626711
tremorCoordAmpSlope 0.0107174
tremorCoordAmpCoV 2.71837
tremorAccAmpMean 0.0169727
tremorAccAmpSlope 0.00168245
tremorAccAmpCoV 0.336742
tremorPcRelVar 0.549202
tremorPcX 0.618389
tremorPcY 0.785872

Spiral Segment 1

Duration 22.4 s, Accuracy Estimate 1.892 (lower is better)

Spiral Segment 2

Duration 18.12 s, Accuracy Estimate 1.817 (lower is better)

Spiral Segment 3

Duration 18.4 s, Accuracy Estimate 1.905 (lower is better)

Spiral Segment 4

Duration 16.52 s, Accuracy Estimate 2.156 (lower is better)

Spiral Segment 5

Duration 17.48 s, Accuracy Estimate 1.954 (lower is better)

Spiral Segment 6

Duration 15.44 s, Accuracy Estimate 2.091 (lower is better)

Spiral Segment 7

Duration 16.92 s, Accuracy Estimate 2.584 (lower is better)

Spiral Segment 8

Duration 13.08 s, Accuracy Estimate 2.537 (lower is better)

Spiral Segment 9

Duration 16.12 s, Accuracy Estimate 2.712 (lower is better)

Spiral Segment 10

Duration 22.4 s, Accuracy Estimate 1.971 (lower is better)

Elel

eDurationMean 0.519444
eDurationStd 0.161748
eDurationStdnorm 0.311387
eDurationMedian 0.485
eDurationQuartdelta 0.0975
eDurationQuartdeltanorm 0.201031
eDurationKurt 5.40829
eDurationTrenddiff -0.0775
eDurationTrendratio 0.850962
eWidthMean 6.84125
eWidthStd 3.41105
eWidthStdnorm 0.4986
eWidthMedian 5.9085
eWidthQuartdelta 2.925
eWidthQuartdeltanorm 0.49505
eWidthKurt 3.90493
eWidthTrenddiff 0.117
eWidthTrendratio 1.02
eHeightMean 9.18775
eHeightStd 2.13138
eHeightStdnorm 0.231981
eHeightMedian 8.7165
eHeightQuartdelta 2.8665
eHeightQuartdeltanorm 0.328859
eHeightKurt 3.00868
eHeightTrenddiff -0.351
eHeightTrendratio 0.961039
eAspectMean 0.723099
eAspectStd 0.249909
eAspectStdnorm 0.345609
eAspectMedian 0.657635
eAspectQuartdelta 0.234628
eAspectQuartdeltanorm 0.356776
eAspectKurt 3.54002
eAspectTrenddiff 0.00695913
eAspectTrendratio 1.01058
eSlantMean 0.0535416
eSlantStd 0.309824
eSlantStdnorm 5.78661
eSlantMedian 0.0663925
eSlantQuartdelta 0.306615
eSlantQuartdeltanorm 4.61822
eSlantKurt 2.6342
eSlantTrenddiff 0.0782752
eRtopMean 0.715072
eRtopStd 0.139254
eRtopStdnorm 0.194741
eRtopMedian 0.72088
eRtopQuartdelta 0.203615
eRtopQuartdeltanorm 0.282454
eRtopKurt 2.25658
eRtopTrenddiff 0.122828
eRbotMean 0.700909
eRbotStd 0.323553
eRbotStdnorm 0.461619
eRbotMedian 0.649616
eRbotQuartdelta 0.462477
eRbotQuartdeltanorm 0.711923
eRbotKurt 2.95248
eRbotTrenddiff -0.0770388
eRrightMean 0.826094
eRrightStd 0.10451
eRrightStdnorm 0.126511
eRrightMedian 0.828083
eRrightQuartdelta 0.142182
eRrightQuartdeltanorm 0.1717
eRrightKurt 3.42635
eRrightTrenddiff 0.0433878
eRleftMean 0.385562
eRleftStd 0.121614
eRleftStdnorm 0.315421
eRleftMedian 0.348082
eRleftQuartdelta 0.145319
eRleftQuartdeltanorm 0.417483
eRleftKurt 4.11565
eRleftTrenddiff -0.0841614
lDurationMean 0.759242
lDurationStd 0.263964
lDurationStdnorm 0.347667
lDurationMedian 0.71
lDurationQuartdelta 0.17375
lDurationQuartdeltanorm 0.244718
lDurationKurt 17.0165
lDurationTrenddiff -0.165
lDurationTrendratio 0.795031
lWidthMean 8.59418
lWidthStd 2.30725
lWidthStdnorm 0.268466
lWidthMedian 8.073
lWidthQuartdelta 2.60325
lWidthQuartdeltanorm 0.322464
lWidthKurt 4.99256
lWidthTrenddiff 1.2285
lWidthTrendratio 1.16279
lHeightMean 23.9637
lHeightStd 3.44784
lHeightStdnorm 0.143877
lHeightMedian 23.751
lHeightQuartdelta 2.9835
lHeightQuartdeltanorm 0.125616
lHeightKurt 4.73732
lHeightTrenddiff -1.4625
lHeightTrendratio 0.940476
lAspectMean 0.365433
lAspectStd 0.101491
lAspectStdnorm 0.277728
lAspectMedian 0.369792
lAspectQuartdelta 0.130286
lAspectQuartdeltanorm 0.352324
lAspectKurt 3.64418
lAspectTrenddiff 0.0869248
lAspectTrendratio 1.26974
lSlantMean 0.0522926
lSlantStd 0.121649
lSlantStdnorm 2.32631
lSlantMedian 0.046875
lSlantQuartdelta 0.141387
lSlantQuartdeltanorm 3.01625
lSlantKurt 3.15569
lSlantTrenddiff 0.0375318
lRtopMean 0.773277
lRtopStd 0.0992534
lRtopStdnorm 0.128354
lRtopMedian 0.792683
lRtopQuartdelta 0.160145
lRtopQuartdeltanorm 0.202029
lRtopKurt 2.8369
lRtopTrenddiff 0.0967992
lRbotMean 0.68859
lRbotStd 0.318737
lRbotStdnorm 0.462884
lRbotMedian 0.71831
lRbotQuartdelta 0.323898
lRbotQuartdeltanorm 0.450917
lRbotKurt 5.83639
lRbotTrenddiff -0.0171724
lRrightMean 0.867861
lRrightStd 0.0791038
lRrightStdnorm 0.091148
lRrightMedian 0.884793
lRrightQuartdelta 0.0747152
lRrightQuartdeltanorm 0.0844438
lRrightKurt 8.69425
lRrightTrenddiff -0.0038631
lRleftMean 0.305363
lRleftStd 0.174044
lRleftStdnorm 0.569957
lRleftMedian 0.234375
lRleftQuartdelta 0.245584
lRleftQuartdeltanorm 1.04783
lRleftKurt 2.80673
lRleftTrenddiff -0.124308

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.999812
sumTouchScores 20.9961
meanMovementTime 0.902
numTouches 21
undershootPercentage 0
overshootPercentage 4.7619

FITTS Long Modified

meanTouchScore 0.868094
sumTouchScores 13.0214
meanMovementTime 1.08893
numTouches 15
undershootPercentage 6.66667
overshootPercentage 6.66667

ZigZag

numZigzags 9
timePerZigzagMean 20.5511
timePerZigzagCoV 0.178946
timePerZigzagSlope 0.0270545
meanError 2.16279
tremorFreq 6.64062
tremorRelPower 29.5896
tremorGyroAmpMean 0.0210344
tremorGyroAmpSlope 0.00216148
tremorGyroAmpCoV 0.419511
tremorCoordAmpMean 0.0525353
tremorCoordAmpSlope 0.00100523
tremorCoordAmpCoV 0.942917
tremorAccAmpMean 0.0283218
tremorAccAmpSlope 0.00121196
tremorAccAmpCoV 0.32892
tremorPcRelVar 0.85966
tremorPcX -0.31897
tremorPcY 0.947765

ZigZag Segment 1

Duration 22.16 s, Accuracy Estimate 1.856 (lower is better)

ZigZag Segment 2

Duration 19.28 s, Accuracy Estimate 2.324 (lower is better)

ZigZag Segment 3

Duration 17.88 s, Accuracy Estimate 2.177 (lower is better)

ZigZag Segment 4

Duration 17.28 s, Accuracy Estimate 2.517 (lower is better)

ZigZag Segment 5

Duration 21.12 s, Accuracy Estimate 1.96 (lower is better)

ZigZag Segment 6

Duration 20.32 s, Accuracy Estimate 1.965 (lower is better)

ZigZag Segment 7

Duration 17.48 s, Accuracy Estimate 2.001 (lower is better)

ZigZag Segment 8

Duration 20.16 s, Accuracy Estimate 2.582 (lower is better)

ZigZag Segment 9

Duration 29.28 s, Accuracy Estimate 2.084 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 21.056
timePerZigzagCoV 0.111409
timePerZigzagSlope -0.00702888
zigzagHeightMean 63.505
zigzagHeightCoV 0.102038
zigzagHeightSlope -0.0634367
meanError 0.0604589
tremorFreq 5.66406
tremorRelPower 27.8326
tremorGyroAmpMean 0.0272423
tremorGyroAmpSlope 0.00280587
tremorGyroAmpCoV 0.312001
tremorCoordAmpMean 0.182345
tremorCoordAmpSlope 0.0182403
tremorCoordAmpCoV 2.68673
tremorAccAmpMean 0.0833673
tremorAccAmpSlope 0.000524567
tremorAccAmpCoV 0.0639812
tremorPcRelVar 0.695056
tremorPcX 0.08014
tremorPcY -0.996784

ZigZag Offset Segment 1

Duration 21.76 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 2

Duration 18.96 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 3

Duration 22.0 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 4

Duration 24.12 s, Accuracy Estimate 0.088 (lower is better)

ZigZag Offset Segment 5

Duration 18.44 s, Accuracy Estimate 0.119 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.36}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7437497490033222}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9257412792684618}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7423820837002755}